Isotonicity of Free Acid GSH in Solution



Now that there is a buffered GSH suitable for inhalation available (GSHPlus from Theranaturals), it would be undesirable to inhale free acid GSH in solution, for that has a pH of 2.7. Nevertheless, in 1998, a gentleman produced this chart of how much sterile water should be added to how much free acid GSH to make the solution isotonic, and that information might be interesting or useful for medical professionals, so we provide that chart here:

Amount of sterile water needed to make an isotonic solution, given the specified amount of free acid GSH. Thereafter, add as much 0.9% saline as desired.

gsh (mg)                          sterile water (ml)
20                                                   0.2
40                                                   0.4
60                                                   0.7
80                                                   0.9
100                                                 1.1
120                                                 1.3
140                                                 1.6
160                                                 1.8
180                                                 2.0
200                                                2.2
220                                                2.5
240                                                 2.7
260                                                 2.9
280                                                 3.1
300                                                 3.4
320                                                 3.6
340                                                 3.8
360                                                 4.0
380                                                 4.2
400                                                 4.5
420                                                 4.7
440                                                 4.9
460                                                 5.1
480                                                 5.4
500                                                 5.6
520                                                 5.8
540                                                 6.0
560                                                 6.3
580                                                 6.5
600                                                 6.7